Drugs: From Discovery to Market
Subject PHRM30008 (2014)
Note: This is an archived Handbook entry from 2014.
|Dates & Locations:|| |
This subject is not offered in 2014.
|Time Commitment:||Contact Hours: 3 x one hour lectures per week (total contact hours: 36) |
Total Time Commitment:
Study Period Commencement:
Study Period Commencement:
Students wishing to undertake this subject as breadth will need the approval of the subject co-ordinator.
|Recommended Background Knowledge:|| |
|Non Allowed Subjects:|| |
This subject cannot be taken if credit has been previously obtained for:
|Core Participation Requirements:||
Prof Gary Anderson
Assoc Prof James Ziogas
Ms Hong Nguyen
This subject will provide an overview of modern drug discovery and development, with an emphasis on the pharmacology that underpins the endeavour. The social, economic and scientific challenges facing contemporary drug discovery and development with respect to choice of suitable drug targets will be discussed; current drug targets, including receptors and enzymes, will be highlighted. Strategies – contrasting the complementary chemical-to-target and target-to-chemical approaches – to identify and optimise lead compounds will be presented. The material will include a discussion of small molecules as well as “biologicals”, such as antibodies and nucleotides. A description of how these lead compounds become drug candidates and are characterised with regards to their pharmacodynamic (receptor binding and activation), pharmacokinetic (ability to reach their site of action) and toxicological/safety pharmacology properties will be provided. Finally the approaches to bring an identified drug candidate to the market will be examined. This part of the subject will consider the necessary human clinical trials, regulatory requirements and ongoing monitoring of approved drugs. The subject material will be presented via a combination of lectures, associated online learning materials, and “hot topic” tutorials. The latter will focus on recent innovations in drug discovery, and will serve to highlight the close relationship between basic science and actual therapeutic agents.
On successful completion of this subject, the students will have developed a clear understanding of the strategies and processes that underpin modern drug discovery and development. They will have detailed knowledge of the pharmacological principles that support drug discovery and development, and therefore of the vital role that pharmacologists play in this endeavour. They will be well placed to appreciate future developments and challenges in the field of drug discovery and development as they occur.
|Prescribed Texts:|| |
Pharmacology, Rang et al., Churchill Livingstone, 6th edition, 2007.
|Breadth Options:|| |
This subject potentially can be taken as a breadth subject component for the following courses:
You should visit learn more about breadth subjects and read the breadth requirements for your degree, and should discuss your choice with your student adviser, before deciding on your subjects.
|Fees Information:||Subject EFTSL, Level, Discipline & Census Date|
By the end of this subject, students will:
This subject is available to students enrolled in the pre 2008 BSc, New Generation BSc, Biomedicine degree.
Biomedical Biotechnology (specialisation of Biotechnology major) |
Biotechnology (pre-2008 Bachelor of Science)
Medicinal Chemistry (specialisation of Chemistry major)
Science credit subjects* for pre-2008 BSc, BASc and combined degree science courses
Science-credited subjects - new generation B-SCI and B-ENG.
Selective subjects for B-BMED
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