Subject 505-944 (2009)

Note: This is an archived Handbook entry from 2009. Search for this in the current handbook

Credit Points: 12.50
Level: 9 (Graduate/Postgraduate)
Dates & Locations:

This subject has the following teaching availabilities in 2009:

For information about these dates, click here.
Time Commitment: Contact Hours: None
Total Time Commitment: 8-12 hours total study time per week

505-105 Mathematics Background for Biostatistics (MMB)
505-107 Principles of Statistical Inference (PSI)
505-108 Data Management & Statistics Computing (DMC)
505-975 Probability and Distribution Theory (PDT)

Corequisites: None
Recommended Background Knowledge: None
Non Allowed Subjects: None
Core Participation Requirements:

For the purposes of considering request for Reasonable Adjustments under the Disability Standards for Education (Cwth 2005), and Student Support and Engagement Policy, academic requirements for this subject are articulated in the Subject Overview, Learning Outcomes, Assessment and Generic Skills sections of this entry.

It is University policy to take all reasonable steps to minimise the impact of disability upon academic study, and reasonable adjustments will be made to enhance a student's participation in the University's programs. Students who feel their disability may impact on meeting the requirements of this subject are encouraged to discuss this matter with a Faculty Student Adviser and Student Equity and Disability Support:


Dr Graham Wood, Macquarie University

Biostatistics Collaboration of Australia

School of Population Health, University of Melbourne

Subject Overview: Bioinformatics addresses problems related to the storage, retrieval and analysis of information about biological structure. This unit will provide a broad-ranging study of this application of quantitative methods in biology. Content will include: biology basics; population genetics; web-based tools, data sources and data retrieval; the analysis of single and multiple DNA or protein sequences; Hidden Markov Models and their applications; evolutionary models; phylogenetic trees; analysis of microarrays; functional genomics; use of R in bioinformatics applications.

To provide an introduction to the field of bioinformatics from a statistical point of view. This will include an understanding of the basic concepts of molecular biology.


Assignments 60% (three written assignments, each worth 20%, approx 6 hrs each) to be submitted during semester. Final at-home examination 40% (approx 12 hrs).

Prescribed Texts:

Durbin R, Eddy S, Krogh A, Mitchison G. Biological Sequence Analysis: Probabilistic Modes of proteins and nucleic acids. Cambridge University Press, 1998. (ISBN 978-0521629713)

Special Computer Requirements: Stata statistical software and Excel (or equivalent)

Resources Provided to Students: Printed course notes and assignment material will be provided to students via post.

Recommended Texts: Sham, P. Statistics in Human Genetics. Arnold: 1998.
Breadth Options:

This subject is not available as a breadth subject.

Fees Information: Subject EFTSL, Level, Discipline & Census Date
Generic Skills: On completion students should have developed independent problem solving, facility with abstract reasoning, clarity of written expression, sound communication of technical concepts.

Links to further information:

This subject is not available in the Master of Public Health.

Related Course(s): Master of Biostatistics
Postgraduate Certificate in Biostatistics
Postgraduate Diploma in Biostatistics

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