Biomolecular Structure & Bioinformatics
Subject 521-307 (2008)
Note: This is an archived Handbook entry from 2008.Search for this in the current handbook
| Credit Points: | 12.500 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Level: | Undergraduate | ||||||||||||
| Dates & Locations: | This subject has the following teaching availabilities in 2008: Semester 2, - Taught on campus.
Timetable can be viewed here. For information about these dates, click here. | ||||||||||||
| Time Commitment: | Contact Hours: 24 lectures (two per week) and 36 hours of practicals and workshops Total Time Commitment: 120 hours | ||||||||||||
| Prerequisites: | 521-301.BBiomedSc students: 521-213, 536-250 and 521-308. | ||||||||||||
| Corequisites: | None | ||||||||||||
| Recommended Background Knowledge: | None | ||||||||||||
| Non Allowed Subjects: | None | ||||||||||||
| Core Participation Requirements: | It is University policy to take all reasonable steps to minimise the impact of disability upon academic study and reasonable steps will be made to enhance a student’s participation in the University’s programs. Students who feel their disability may impact upon their active and safe participation in a subject are encouraged to discuss this with the relevant subject coordinator and the Disability Liaison Unit. |
Coordinator
A/Prof P Gooley| Subject Overview: | Students will acquire knowledge of the fundamental concepts of determination of protein and nucleic acid structure, and bioinformatics (computational molecular biology) necessary for those who wish to continue studies in relevant areas of structural biology, bioinformatics, protein engineering and rational drug design. Students will also gain an appreciation of the Human Genome Project and its impact on the developing fields of bioinformatics, structural genomics, protein pharmaceuticals and drug discovery. This subject gives an overview of the theory and application of methodologies for the determination and computational analyses of macromolecular structures using Nuclear Magnetic Resonance (NMR) spectroscopy, X-ray crystallography, protein molecular dynamics, protein fold recognition, and gene and protein database mining; and the biophysical methods for investigating macromolecular recognition and interaction. Subject content includes principles and practice of X-ray crystallography and NMR spectroscopy for determining the three-dimensional structures of biomolecular complexes; the application of X-ray crystallography and nuclear magnetic resonance spectroscopy to structural genomics, rational drug design and screening; use of gene and protein databases to detect biologically significant data; biophysical methods for determining the conformations of proteins and nucleic acids in aqueous solution; and molecular dynamics of proteins and the principles of macromolecular recognition including computer-based modelling. In addition to the specific skills gained through study of this subject, students should develop problem-solving and communication skills in tutorials and report writing. |
|---|---|
| Assessment: | Ongoing assessment of practical and laboratory work during the semester (30%); a 2-hour written examination in the examination period (70%). |
| Prescribed Texts: | None |
| Breadth Options: | This subject is a level 2 or level 3 subject and is not available to new generation degree students as a breadth option in 2008. This subject or an equivalent will be available as breadth in the future. Breadth subjects are currently being developed and these existing subject details can be used as guide to the type of options that might be available. 2009 subjects to be offered as breadth will be finalised before re-enrolment for 2009 starts in early October. |
| Fees Information: | Subject EFTSL, Level, Discipline & Census Date |
| Notes: | Students enrolled in the BSc (pre-2008 BSc), BASc or a combined BSc course will receive science credit for the completion of this subject. |
| Related Course(s): |
Bachelor of Arts and Bachelor of Science Bachelor of Arts and Sciences Bachelor of Biomedical Science Bachelor of Science Graduate Diploma in Biotechnology |
Download PDF version.