Functional Genomics and Bioinformatics

Subject BCMB30002 (2010)

Note: This is an archived Handbook entry from 2010.

Credit Points: 12.50
Level: 3 (Undergraduate)
Dates & Locations:

This subject has the following teaching availabilities in 2010:

Semester 1, Parkville - Taught on campus.
Pre-teaching Period Start not applicable
Teaching Period not applicable
Assessment Period End not applicable
Last date to Self-Enrol not applicable
Census Date not applicable
Last date to Withdraw without fail not applicable


Timetable can be viewed here. For information about these dates, click here.
Time Commitment: Contact Hours: three x 1 hour lecture, and one x 1 hour tutorial per week.
Total Time Commitment: 48 contact hours with an estimated total time commitment of 120 hours.
Prerequisites:

BSc students

Before 2009:
Biochemistry & Molecular Biology Part A (521-211)
Biochemistry & Molecular Biology Part B (521-212) 2009 and subsequently:
Subject
Study Period Commencement:
Credit Points:
Note that the pre-2009 subject “Biochemistry & Molecular Biology Part A” and the 2009 subject “Biochemistry & Molecular Biology” are not identical despite having the same subject code. Only the subject “Biochemistry & Molecular Biology” offered in 2009 and subsequently acts as a stand-alone prerequisite. Other combinations that provide similar background will be considered by the coordinator.

BBiomedicine students

Subject
Study Period Commencement:
Credit Points:
BBiomedSc students (pre-2009)
521-213 Integrated Biomedical Science I
536-250 Integrated Biomedical Science II
Corequisites: None
Recommended Background Knowledge: None
Non Allowed Subjects: Students cannot enrol in and gain credit for this subject if previously obtained credit for pre-2009 subject 521-302 Functional Genomics.

BBiomedSc students who have received credit for 521-308 Genome Science are not permitted to enrol and gain credit for this subject.
Core Participation Requirements: For the purposes of considering request for Reasonable Adjustments under the Disability Standards for Education (Cwth 2005), and Students Experiencing Academic Disadvantage Policy, academic requirements for this subject are articulated in the Subject Description, Subject Objectives, Generic Skills and Assessment Requirements of this entry.
The University is dedicated to provide support to those with special requirements. Further details on the disability support scheme can be found at the Disability Liaison Unit website:

http://www.services.unimelb.edu.au/disability/

Coordinator

Dr Alana Mitchell

Contact

amitch@unimelb.edu.au
Subject Overview:

The knowledge of genome structures from various organisms and rapid development of technologies that exploit this information are driving revolutions in biology, medicine and biotechnology. This subject describes the structure and expression of genomes in higher organisms and provides an understanding of technologies to analyse and manipulate genes. We demonstrate how the modification of genes in cells and whole organisms can be used to discover gene function or to modify phenotype. The structure of eukaryotic chromosomes is presented to demonstrate how genetic material is replicated and how transcription of RNA is controlled. We illustrate how regulatory pathways at the RNA and protein levels are integrated to control cell metabolism and cell fate. Bioinformatic techniques that are key to understanding genomic information will be explained with examples of how these tools are applied. Functional genomic approaches to investigate cancer will be used to exemplify how molecular biology can be applied to the study of human biology and health. This subject is required for completion of a major in Biochemistry and Molecular Biology.
Objectives:

By the end of the subject, the student should understand:

  • current concepts concerning the molecular bases of genome structure and the regulation of gene expression in eukaryotic organisms (yeast, animals and plants);
  • the role of gene regulatory networks in regulating metabolic and developmental pathways;
  • theoretical background to recombinant DNA technology and an appreciation of its biomedical and biotechnological applications;
  • the significance and applications of human and related genome sequencing programs;
  • bioinformatic techniques and applications;
  • how gene function can be investigated by recombinant DNA techniques and genetic manipulation of cell lines and whole organisms (transgenesis and targeted mutation);
  • how functional genomic approaches can be applied to study human diseases such as cancer.
Assessment:
  • 3 hour written exam held in examination period (70%);
  • two 1 hour written examinations held during semester (7.5% x 2 = 15%);
  • 1,000 word essay assessment due mid-semester (15%).
Prescribed Texts:

Alberts et al, Molecular Biology of the Cell, 5th edition

Lodish et al, Molecular Cell Biology, 4th edition
Breadth Options:

This subject is not available as a breadth subject.
Fees Information: Subject EFTSL, Level, Discipline & Census Date
Generic Skills:

On completion of this subject, students should have developed the following generic skills:

  • the ability to interpret scientific literature and interpret data from electronic databases.
  • the capacity to integrate knowledge across disciplines.
  • the ability to comprehend a question, evaluate the relevant information and communicate an answer.
Notes:

Students enrolled in the BSc (pre-2008 BSc), BASc or a combined BSc course will receive science credit for the completion of this subject.

Students undertaking this subject will be expected to regularly access an internet-enabled computer.
Related Course(s): Bachelor of Biomedical Science
Bachelor of Science
Graduate Diploma in Biotechnology
Related Majors/Minors/Specialisations: Agri-food Biotechnology
Animal Cell Biology
Biochemistry and Molecular Biology
Biochemistry and Molecular Biology
Biochemistry and Molecular Biology
Biomedical Biotechnology
Biotechnology
Biotechnology
Cell Biology
Cell and Developmental Biology
Reproduction and Development

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